Polysaccharide matrices comprising macromolecular spacer arms fo

Details Polysaccharide matrices comprising macromolecular spacer arms fo Polysaccharide matrices comprising macromolecular spacer arms fo

1981-07-27

1983-10-25

Kight, III, John

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260112R, 424177, 424178, 536 551, C07G 700

Patent

active

044118325

ABSTRACT:
Polysaccharide matrices, including polyfunctional macromolecular spacer "arms" coupled to the backbones of such matrices in multipoint attachment, are useful as adsorbents in affinity chromatography techniques to "separate" the matrix from the specific liquid being chromatographed. Exemplary preferred polyfunctional macromolecules include [1] poly-L-lysine, [2] the graft copolymer, poly(L-lysyl-DL-alanine), [3] native albumin and [4] denatured albumin.

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patent: 4225487 (1980-09-01), Cuatrecasas et al.
Science, 179, pp. 1142-1144, "Biological Activity of Insulin-Sepharose", Cuatrecasas.
Chem. Absts., vol. 79, (1973), 75505h, Wilchek, "Stable and High-Sepharose-Affinity Chromatography".
Journal of Biological Chemistry, 248, No. 18, Sica et al., (3/19/73), pp. 6543-6558.

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