Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1986-07-25
1988-08-02
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514211, 514212, 514218, 514254, 5142325, 5142345, 544116, 544284, 544292, A61K 31505, C07D23984
Patent
active
047614161
ABSTRACT:
Pharmaceutical compositions comprising, or compositions consisting essentially of, compounds according to the formula ##STR1## or an optical isomer thereof are disclosed, wherein the substituents A, Z and R.sup.1 are defined herein. The invention is also directed to certain compounds of the above class. The compounds of Formula I are cyclic AMP phosphodiesterase inhibitors useful as antithrombotic and inotropic agents and the like in mammals.
REFERENCES:
patent: 3496179 (1970-02-01), Hess
patent: 4146718 (1979-03-01), Jenks et al.
patent: 4294851 (1981-10-01), Metz et al.
patent: 4490371 (1984-12-01), Jones et al.
patent: 4551459 (1985-11-01), Jones et al.
patent: 4596806 (1986-06-01), Ishikawa et al.
Fried John H.
Venuti Michael C.
Hollrah Glennon H.
Krubiner Alan M.
Moran Tom M.
Syntex (U.S.A.) Inc.
Toth Liza K.
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