Dibenzopyrimidoazepines

Details Dibenzopyrimidoazepines Dibenzopyrimidoazepines

1976-01-08

1977-11-01

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260239D, 2602393T, 424251, C07D48704, C07D22320, A61K 3155

Patent

active

040565297

ABSTRACT:
The invention relates to dibenzopyrimidoazepines of the formula (I) ##STR1## and their acid addition and quaternary ammonium salts. In formula (I) R.sup.1 and R.sup.2 each represent hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl and X represents two hydrogen atoms, an oxo group, a protected oxo group or an oximino group. The compounds in which X represents two hydrogen atoms, an oxo group or an oximino group possess hypoglycaemic activity. The compound in which X represents a protected oxo group are intermediates for preparing the compounds in which X is an oxo group. The dibenzopyrimidoazepines may be prepared by cyclising or cyclodehydrating novel morphanthridine derivatives.

REFERENCES:
patent: 3646009 (1972-02-01), Winter et al.
patent: 3892695 (1975-07-01), VANDER Burg
VANDER Burg, Eur. J. Clin, Pharmacol, 5(3)166-73, (1973), abstract only supplied.
Nagarajan et al., Indian J. Chemistry, 12, pp. 263-9, Mar. 1974.

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