Programmable apparatus for reducing substance dependency in tran

Details Programmable apparatus for reducing substance dependency in tran Programmable apparatus for reducing substance dependency in tran

1995-01-09

1996-07-23

Green, Randall L.

Surgery

Means for introducing or removing material from body for...

Infrared, visible light, ultraviolet, x-ray or electrical...

607 58, 607900, A61N 130

Patent

active

055385036

ABSTRACT:
An apparatus is described for the programmable iontophoretic or iontophoretic-ultrasonic (ionosonic) transdermal delivery of medication across the skin or other biological membrane. In one embodiment, the programmable apparatus controls the depth of penetration of a medicament into the skin. In another embodiment the programmed delivery of medicament is accompanied by an electrical stimulus for treating substance abuse. The apparatus can be adapted for large dermal area application or for a smaller area of application, depending on the choice of specific electrode employed. In a preferred embodiment the apparatus comprises a multichannel iontophoretic applicator electrode. Multiple piezoelectric elements are mounted on the iontophoretic electrode. The combination of ultrasonic vibration and iontophoresis improves the penetration of medicament in contact with the skin or mucous membrane underlying the electrode which can be programmably controlled by a CPU through the use of a EPROM. A wearable embodiment of an ionosonic or iontophoretic drug delivery system employing programmability may be used to produce response conditioning useful for the outpatient treatment of obesity, nicotine detoxification, and narcotic addiction detoxification.

REFERENCES:
patent: 4211222 (1980-07-01), Tapper
patent: 4708716 (1987-11-01), Sibalis
patent: 4767402 (1988-08-01), Kost et al.
patent: 4950229 (1990-08-01), Sage, Jr.
patent: 5002527 (1991-03-01), Reller et al.
patent: 5115805 (1992-05-01), Bommannan et al.

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