Cephalosporin-1-oxide derivatives

Details Cephalosporin-1-oxide derivatives Cephalosporin-1-oxide derivatives

1982-09-07

1985-03-12

Coughlan, Jr., Paul M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544 22, 544 25, 544 27, 544 28, 514203, 514205, 514206, 514207, A61K 31545, C07D50118

Patent

active

045044783

ABSTRACT:
An antibacterial cephalosporin derivative of the formula I: ##STR1## in which X.sup.1 is sulphinyl; R.sup.1 is any one of the C-3 substituents from antibacterially-active cephalosporins known in the art; R.sup.2 is any one of the C-4 substituents from antibacterially-active cephalosporins known in the art; R.sup.3 is hydrogen, 1-6C alkoxy or 1-6C alkylthio; X.sup.2 is nitrogen or a radical N.sup..sym. R.sup.5 ; R.sup.4 and R.sup.5 are a variety of radicals described in the specification; --A-- is of the formula II or III: ##STR2## in which R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10 and R.sup.11 are a variety of substituents described in the specification; and the pharmaceutically-acceptable acid- and base-addition salts thereof. Pharmaceutical compositions and manufacturing processes are also described.

REFERENCES:
patent: 4358447 (1982-11-01), Hannah
de Koning et al., "Stereospecific Synthesis of Biologically Active Cephalosporin R-Sulphoxides" Chap. 17 in Recent Advances in the Chemistry of B-lactam Antibiotics pub. by Chemical Society, London in 1977 as Spec. Pub. 28.

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