Method of inhibiting squalene synthetase

Details Method of inhibiting squalene synthetase Method of inhibiting squalene synthetase

1996-01-16

1997-04-29

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514 86, 514102, 514107, 544243, 548112, 548119, 558158, 562 13, A61K 31675, A61K 31685, A61K 3166

Patent

active

056249179

ABSTRACT:
There is provided a squalene inhibitory composition containing a 1,1-bisphosphonic acid compound, a lower alkyl ester thereof, or a salt thereof, which is useful for treating hypercholesterolemia. There are also provided novel compounds having squalene synthetase inhibitory activity and a pharmaceutical composition for treating hypercholesterolemia containing a 1,1-bisphosphonic compound, a lower alkyl ester thereof or a salt thereof.

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