Process for preparation of 9-(dihalobenzyl)adenines

Details Process for preparation of 9-(dihalobenzyl)adenines Process for preparation of 9-(dihalobenzyl)adenines

1979-10-23

1983-10-25

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

424253, C07D47334

Patent

active

RE0314293

ABSTRACT:
9-(Dihalobenzyl)adenines are prepared uncontaminated with other positional isomers in a series of mild transformations starting from 4,5,6-triaminopyrimidine and proceeding via 7-(N-formyl-N-dihalobenzyl)amino[1,2,5]-thiadiazolo[3,4-d]pyrimidine. The resulting compounds have anticoccidial activity and are useful in controlling cecal and/or intestinal coccidiosis when administered in minor quantities to animals, in particular to poultry usually in admixture with animal sustenance.

REFERENCES:
patent: 3813394 (1974-05-01), Tensho et al.
patent: 3846426 (1974-11-01), Lira et al.
patent: 4100159 (1978-07-01), Zwann
patent: 4171440 (1979-10-01), Shinkai et al.
Taylor et al., J. Chem. Soc., 36 3211-3217, (1971).
Shealey et al., J. Org. Chem., 27 2154-2160, (1962).
Hallstein et al. (Mutation Research 65 133-142 (1979).
Purchase et al. (British Journal of Cancer 37 873-903 (1978).

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