Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant...
Patent
1986-03-11
1988-08-02
Terapane, John F.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
424 9, 128 11, A61N 512, A61K 4300, A61K 4100
Patent
active
H00005053
ABSTRACT:
A stable boronated (.sup.10 B-labeled) compound, sodium mercaptoundecahydrododecaborate is infused in the form of the disulfide dimer, [.sup.10 B]Na.sub.4 B.sub.24 H.sub.22 S.sub.2, at a dose of about 200 .mu.g .sup.10 B per gm body weight. The infusion is performed into the blood or peritoneal cavity of the patient slowly over a period of many days, perhaps one week or more, at the rate of roughly 1 .mu.g .sup.10 B per gm body weight per hour. Use of this particular boronated dimer in the manner or similarly to the manner so described permits radiotherapeutically effective amounts of boron to accumulate in tumors to be treated by boron neutron capture radiation therapy and also permits sufficient retention of boron in tumor after the cessation of the slow infusion, so as to allow the blood concentration of .sup.10 B to drop or to be reduced artificially to a radiotherapeutically effective level, less than one-half of the concentration of .sup.10 B in the tumor.
REFERENCES:
Hatanaka, et al., "A Revised Boron-Neutron Capture Therapy for Malignant Brain Tumors", Z. Neurol., 204, 309-332 (1973).
Tolpin, et al., "Boron Neutron Capture Therapy of Cerebral Gliomas", Oncology 32: 223-246 (1975).
Fairchild Ralph G.
Micca Peggy L.
Slatkin Daniel N.
Bogosian Margaret C.
Hightower Judson R.
Terapane John F.
The United States of America as represented by the United States
Thomas J. E.
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