Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1996-08-09
1999-09-28
Pak, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514 76, 514 77, 514558, 514905, 424438, 424442, 426 74, 426656, 426807, 562 8, 562562, C07C22926, A23K 118, A23K 116, A23K 1175
Patent
active
059589779
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
This invention relates to an additive composition to be used in a feed for ruminant mammals. More particularly, it relates to an additive composition for use in a powdery or homogeneously granular feed for ruminant mammals which is stable in the first compartment of the stomach, i.e., rumen of a ruminant mammal and is capable of releasing a basic amino acid in the fourth compartment of the stomach, i.e., abomasum, and the subsequent digestive organs of the ruminant mammal.
BACKGROUND ART
In such ruminant mammals as cows and sheep, when such biologically active substances as amino acids and vitamins are directly administered orally, they are mostly hydrolyzed by microorganisms inhabiting rumen and are prevented from being utilized effectively. Such a rumen bypass preparation for ruminant mammals as is capable of protecting such a biologically active substance from the hydrolysis by the microorganisms in the rumen and enabling it to be digested and absorbed in the abomasum and the subsequent digestive organs, therefore, is important in the field of feeds, nutritive agents, and animal medicines for ruminant mammals.
For the manufacture of ruminant feed additives containing biologically active substances, methods which comprise dispersing a biologically active substance in a matrix formed of such a protective substance as a hydrophobic substance like oil or fat or a basic macromolecular substance and granulating the resultant composite or methods which comprise coating seeds containing a biologically active substance with such an acid sensitive substance as a hydrophobic substance like oil or fat or a basic macromolecular substance have been proposed to date.
As one of the methods resorting to the dispersion of a biologically active substance in a protective substance, JP-A-60-168,351, for example, proposes a method which comprises causing a biologically active substance to incorporate therein not less than 20% by weight of calcium carbonate and not less than 10% by weight of an aliphatic monocarboxylic acid having 14 or more carbon atoms, a cured oil or fat, etc. as well and granulating the resultant mixture. JP-B-59-10,780 proposes another method which comprises dispersing 30 to 50% by weight of a biologically active substance in a protective substance composed of 10 to 35% by weight of a salt of an aliphatic monocarboxylic acid having 14 to 22 carbon atoms or ricinoleic acid and the balance of an aliphatic monocarboxylic acid having 14 to 22 carbon atoms, ricinoleic acid, a cured oil or fat, etc.
As one of the methods resorting to coating a biological substance with a hydrophobic protective substance, JP-A-63-317,053, for example, proposes a method which comprises coating a biologically active substance with a protective agent composed of an aliphatic monocarboxylic acid having 12 to 24 carbon atoms, a cured oil or fat, lecithin, and a glycerin aliphatic ester.
As methods resorting to coating a biologically active substance with an acid sensitive protective substance, JP-A-54-46,823, for example, proposes a method which fulfills the coating with a coating composition containing a film-forming basic macromolecular substance and JP-A-04-217,625 proposes a method which resides in spray coating zein in the form of a water emulsion or a water dispersion.
The methods involving the dispersion of a biologically active substance in a protective substance, however, require the content of the biologically active substance to be appreciably lowered with due respect to the capacity for protection because the biologically active substance is present in the proximity of the surface of particles. In view of the fact that the biologibally active substance, when soluble in water, has a retention time in the range of ten-odd hours to several days in the rumen, the methods incur difficulty in affording necessary protection.
A method which resides in coating seeds containing a biologically active substance with an acid sensitive macromolecular substance or a hydrophobic protective substance has been also pro
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Ikeda Toru
Yukawa Toshihide
Ajinomoto Co. Inc.
Pak John
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