Pristinamycin II.sub.B derivatives and compositions containing t

Details Pristinamycin II.sub.B derivatives and compositions containing t Pristinamycin II.sub.B derivatives and compositions containing t

1986-01-10

1987-05-26

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

530317, 540455, A61K 3142, C07D49814, C07K 512

Patent

active

046686690

ABSTRACT:
Pristinamycin II.sub.B derivatives of formula: ##STR1## in which R denotes a nitrogen-containing 4 to 7-membered heterocyclic ring optionally substituted by alkyl; or alkyl (2 to 4 C) substituted by 1 or 2 phenyl, cycloalkylamino or N-alkyl-N-cycloalkylamino (3 to 6 ring atoms), alkylamino, dialkylamino or dialkylcarbamoyloxy radicals (the dialkylamino moieties of these 2 latter radicals being capable of forming a 4 to 7-membered cyclic ring optionally substituted by alkyl) or substituted by 1 or 2 nitrogen-containing 4 to 7 membered heterocyclic rings, optionally substituted by alkyl, at least one of the above substituents being a nitrogen-containing substituent capable of forming salts and n is 1 or 2, all the alkyls being linear or branched and containing (unless stated otherwise) 1 to 10 carbon atoms, their isomers, their salts and their preparation. These compounds, optionally in combination with known synergistins or synergistins of formula: ##STR2## are useful as antimicrobial agents.

REFERENCES:
patent: 4590004 (1986-05-01), Corbet et al.
Chemical Abstracts, vol. 101, 1984; p. 726, Ref. No. 191457r.
Bulletin Soc. Chimique de France, No. 2, 1968, pp. 585-591.
The Journal of Antibiotics, vol. XXXVII, No. 10, Oct. 1984, pp. 1246-1252.
Chemical Abstract, vol. 100, 1984, p. 564, Ref. No. 209476n.
Noller, "Chemistry of Organic Compounds", 2nd Ed., (Saunders) (1957) pp. 283-286.

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