Polypeptides with an anticoagulant action, a process to prepare

Details Polypeptides with an anticoagulant action, a process to prepare Polypeptides with an anticoagulant action, a process to prepare

1985-04-17

1987-05-26

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, A61K 3743, C07K 710

Patent

active

046686622

ABSTRACT:
The invention relates to polypeptides of the formula I ##STR1## in which m denotes 0-50, n denotes 0-100 and R denotes the phenolic hydrogen or a phenol ester group, X represents identical or different residues of naturally occurring .alpha.-amino acids, Y denotes Val, Ile, Thr, Leu or Phe, and Z represents identical or different residues of naturally occurring .alpha.-amino acids, and in which the Cys residues are linked pairwise via disulfide bridges, to a process for preparing or obtaining them and to agents containing them.

REFERENCES:
Biochimica et Biophysics Acta 310 (1973) 416-417.
Febs 1104 165, No. 2, (1984) 180-184.
Biochim. Biophys. Acta, 93 (1964) 40-44.
Bull. Soc. Chim. Biol. (1963) 45, 55-67.
Hirudin (The Merck Index, 9th Ed. (1976) p. 4593.

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