Substituted indazole derivatives

Details Substituted indazole derivatives Substituted indazole derivatives

1997-06-25

1999-09-28

Fan, Jane

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514338, 546256, 5462757, A61K 3144, C07D40104

Patent

active

059589531

ABSTRACT:
The invention relates to compounds of the formula ##STR1## and to pharmaceutically acceptable salts thereof, wherein the broken line in formula I indicates a single or double bond, and wherein R, R.sub.1, X.sub.1 and X.sub.2 are as defined herein. The invention further relates to pharmaceutical compositions containing the compounds of formula I, and to methods of inhibiting phosphodiesterase type IV or the production of tumor necrosis factor in a mammal by administering the compounds of formula I to said mammal.

REFERENCES:
patent: 5776932 (1998-07-01), Schindler et al.
CA 74:141628, Land et al., 1971.

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