Substituted pyrazoles as CRF antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514406, 546152, 5483731, 5483751, C07D40106, A61K 31415

Patent

active

059589485

ABSTRACT:
The compounds of the formula wherein A, R.sub.1, R.sub.3, X.sub.1, Y and Z are as defined herein, have corticotropin-releasing factor (CRF) antagonist activity. They are useful in the treatment of illnesses induced by CRF, such as stress and anxiety related disorders.

REFERENCES:
patent: 4605642 (1986-08-01), Rivier et al.
patent: 5063248 (1991-11-01), Abren et al.

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