Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-05-06
1999-09-28
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544280, 544278, A61K 31505, C07D48704
Patent
active
059589302
ABSTRACT:
This invention discloses compounds, and pharmaceutically acceptable salts thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include cancer, and secondary infections caused by Pneumocystis carinii and Toxoplasmosis gondii in immunocompromised patients. The compounds themselves, methods of making these compounds, and methods of using these compounds are all disclosed.
REFERENCES:
patent: 4435570 (1984-03-01), Nishimura et al.
patent: 4923872 (1990-05-01), Kostlan et al.
patent: 4996206 (1991-02-01), Taylor et al.
patent: 5028608 (1991-07-01), Taylor et al.
patent: 5248775 (1993-09-01), Taylor et al.
patent: 5254687 (1993-10-01), Taylor et al.
patent: 5344932 (1994-09-01), Taylor
1991, vol. 34, No. 2 p. 556. Antifolates: Synthesis and Biological Activities", Journal of Medicinal Chemistry, 1994, pp. 1169-1176, vol. 37, No. 8. as Classical and Nonclassical Antifolate Inhibitors of Dihydrofolate Reductases", Journal of Medicinal Chemistry, 1995, pp. 2158-2165, vol. 38, No. 12.
Gangjee et al., "Effect of Bridge Region Variation on Antifolate and Antitumor Activity of Classical 5-Substituted pp 3798-3805, vol. 38, No. 19.
Gangjee et al., "5-Arylthio-Substituted Synthase Inhibitors and Antitumor Agents", Journal of Medicinal Chemistry, 1995, pp. 4495-4502, vol. 38, No. 22. Nonclassical Antifolate Inhibitors of Thymidylate Synthase", J. Med. Chem., 1996, pp. 4563-4568, vol. 39, No. 23.
Gangjee et al., "Classical and Nonclassical Antifolates as Potential Antitumor, Antipheumocystis and Antitoxoplasma Agents", Current Pharmaceutical Design, 1996, pp. 263-280, vol. 2.
Gangjee et al., "Effect of N.sup.9 -Methylation and Bridge Atom Variation against Dihydrofolate Reductases from Pneumocystis carinii and Toxoplasma gondii", J. Med. Chem., 1997, pp. 1173-1177, vol. 40.
Cody et al., "Comparison of Ternary Complexes of Pneumocystis carinii and Wild-Type Human Dihydrofolate Reductaces with Conenzyme NADPH and a Novel pp. 638-649, vol. D53. Inhibits Multiple Folate-requiring Enzymes", Cancer Research, Mar. 15, 1997, pp. 1116-1123, vol. 57.
Gangjee et al., "Synthesis and Biological Activities of Tricyclic Conformationally Restrcited Tetrahydropyrido Annulated Chem., 1998, pp. 1409-1416, vol. 41.
Gangjee et al., "Selective Pheumocystis carinii Dihydrofolate Reductase Inhibitors: Design, Synthesis, and Biological Evaluation of New Chemistry, 1998, pp. 1263-1271, vol. 44, No. 8.
Duquesne University of the Holy Ghost
Meyers Diane R.
Raymond Richard L.
Silverman Arnold B.
Sripada Pavanaram K
LandOfFree
Pyrrolo pyrimidine and furo pyrimidine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pyrrolo pyrimidine and furo pyrimidine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyrrolo pyrimidine and furo pyrimidine derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-703504