Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant...
Patent
1984-03-19
1987-05-26
Nucker, Christie M.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
424 9, 424 85, 436548, 530389, 530391, 530409, 534 14, 935107, 935108, A61K 4300, A61K 4902, A61K 3900
Patent
active
046685030
ABSTRACT:
Amines, including proteins and polypeptides covalently coupled with a chelating agent such as diethylenetriaminepentaacetic acid (DTPA) can be labeled with .sup.99m Tc in the presence of a stannous reducing agent at near neutral pH by maintaining the protein concentration at a low level and the DTPA concentration at a high level. The .sup.99m Tc is labeled to the protein through the DTPA sites linked to the protein. Utilizing .sup.111 In labeled proteins as controls, it is shown that the .sup.99m Tc labeled proteins are labeled at the DTPA sites and that they exhibit in vivo stabilities equal to that of the .sup.111 In labeled proteins.
REFERENCES:
patent: 4479930 (1984-10-01), Hnatowich
Sundberg et al., J. Med. Chem., 17(1974) 1304-7.
Cook Paul J.
Nucker Christie M.
Trustees of University of Massachusetts
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