Predicting folded structures of proteins

Details Predicting folded structures of proteins Predicting folded structures of proteins

1992-03-25

1999-09-28

Redding, David A.

Chemistry: analytical and immunological testing

Peptide, protein or amino acid

436 89, 3644131, G01N 3300, G06F 1500

Patent

active

059587849

ABSTRACT:
A method is presented for predicting the folded structure of proteins that comprises obtaining an alignment of the sequences of a set of homologous proteins, using patterns of conservation and variation of the sequence between proteins with clearly defined evolutionary relationships to assign positions in the alignment to the surface of the folded structure, the inside of the folded structure, active site, or parsing segments, assigning secondary structures by identifying periodicity in said assignments, and then assembling the secondary structural units into a globular form using distance constraints imposed by disulfide bridges, active site assignments, and covariation analysis.

REFERENCES:
patent: 5265030 (1993-11-01), Skolnick et al.
patent: 5436850 (1995-07-01), Eisenberg et al.

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