Compositions and methods for mediating cell cycle progression

Details Compositions and methods for mediating cell cycle progression Compositions and methods for mediating cell cycle progression

1996-01-18

1999-09-28

Saunders, David

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

435325, 4353201, 514 44, 536 231, 536 245, C12N 1579, C12N 510, A01N 4304, C07H 2104

Patent

active

059587695

ABSTRACT:
Inhibitors of the p27 cyclin dependent kinase inhibitor protein or sequences encoding the protein modulate vertebrate cell cycle progression and increase the proportion of dividing cells to non-dividing cells in a population of treated cells. As the proportion of dividing cells increases, the cell population, e.g., hematopoietic progenitor (stem) cells, is more efficiently used for gene therapy applications.

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