Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-12-02
1999-09-28
Ulm, John
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4352523, 4353201, 536 235, 536 2431, C12N 510, C12N 1512
Patent
active
059587296
ABSTRACT:
A human G-protein receptor HCEGH45 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for identifying antagonists and agonists to such polypeptide. Antagonists against such polypeptides may be used therapeutically to treat PACAP hypersecretory conditions and to create pharmacological amnesia models while the agonists may be employed to treat amnesia and Alzheimer's disease. Also disclosed are diagnostic methods for detecting a mutation in the receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.
REFERENCES:
patent: 5328838 (1994-07-01), Galli et al.
patent: 5366889 (1994-11-01), McDonald et al.
Bischoff et al., EP Journal of Immunology, vol. 23:761-767 (1993).
Iismaa, T.P. et al., Genomics 24: 391-394 (1994).
Schweickart, V.L. et al., Genomics 23: 643-650 (1994).
Heiber, M. et al., DNA and Cell Biology 14: 25-35 (1995).
Hata, S. et al., Biochimica et Biophysica Acta1261: 121-125 (1995).
Marchese, A. et al., Biochemical & Biophysical Research Comm. , 205: 1952-1958 (1994).
Marchese, A. et al., Genomics 23: 609-618 (1994).
Database EMBL Nucleotide Sequences Accession No. N95759 & W24853 (1996).
Ross, P. C. et al., Proc. Natl. Acad. Sci., 87: 3052-3056 (1990).
Libert, F. et al., Science 244: 569-572 (1989).
Eva, C. et al., FEBS 271:81-84 (1990).
Hla, T. et al., J. of Biol. Chem., 265: 9308-9313 (1990).
Meyerhof, W. et al., FEBS 284: 155-160 (1991).
Scott, J.K., et al., Science 249: 386-249 (1990).
Nagase, T., et al., DNA Research 3: 321-329 (1996).
Li Yi
Rosen Craig A.
Ruben Steven M.
Soppet Daniel R.
Brookes A. Anders
Human Genome Sciences Inc.
Ulm John
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