Siloxane MQ resin vesicles and entrapment

Details Siloxane MQ resin vesicles and entrapment Siloxane MQ resin vesicles and entrapment

1995-01-13

1999-09-28

Moore, Margaret G.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

523105, 4284022, 4284024, 42840224, A61K 951

Patent

active

059584483

ABSTRACT:
A method of entrapping a water-soluble substance in vesicles formed from a surface active siloxane is carried out by dissolving the substance to be entrapped in water, adding the surface active siloxane, mildly agitating the mixture, and removing excess water and substance. Water-insoluble substances are entrapped in the vesicles by dissolving the substance to be entrapped in the surface active siloxane, and mildly agitating the substance and the siloxane. The surface active siloxanes consist essentially of tetravalent SiO.sub.2 units, and monovalent R.sub.3 SiO.sub.1/2 and R'R.sub.2 SiO.sub.1/2 units. The ratio of monovalent units to tetravalent units is from 0.4/1 to 2/1, and from 40 to 90% of all monovalent units are R'R.sub.2 SiO.sub.1/2 units. R is a monovalent hydrocarbon group with up to eight carbon atoms, and R' is a polyoxyalkylene group.

REFERENCES:
patent: 3887601 (1975-06-01), Kanner et al.
patent: 4774310 (1988-09-01), Butler
patent: 5364633 (1994-11-01), Hill
patent: 5411744 (1995-05-01), Hill et al.

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