Synthetic compounds and compositions with enhanced cell binding

Details Synthetic compounds and compositions with enhanced cell binding Synthetic compounds and compositions with enhanced cell binding

1997-05-20

1999-09-28

Davenport, Avis M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

424484, 514 14, 514 15, 514 16, 514 17, 514 18, 514 19, 530345, A61K 900, A61K 914, A61K 3800, C07K 500

Patent

active

059584289

ABSTRACT:
Compositions of the invention include composites comprising a biomaterial having compounds thereon with enhanced cell binding with respect to collagen. These composites are useful for soft and hard tissue repair or reconstruction and for in vitro uses. Suitable compounds with enhanced cell binding include synthetic peptides that mimic the conformation necessary for recognition and docking of collagen binding species (such as cell surface receptors for collagen and fibronectin) and have the amino acid residues -Ile-Ala- folded in a .beta.-bend.

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