Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure
Patent
1997-12-12
1999-09-28
Dees, Jose' G.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Molecular bilayer structure
424 129, 424 137, A61K 5112
Patent
active
059583711
ABSTRACT:
A method for ligand-based binding of lipid encapsulated particles to molecular epitopes on a surface in vivo or in vitro comprises sequentially administering (a) a site-specific ligand activated with a biotin activating agent; (b) an avidin activating agent; and (c) lipid encapsulated particles activated with a biotin activating agent, whereby the ligand is conjugated to the particles through an avidin-biotin interaction and the resulting conjugate is bound to the molecular epitopes on such surface. The conjugate is effective for imaging by x-ray, ultrasound, magnetic resonance, positron emission tomography or nuclear imaging. Compositions for use in ultrasonic imaging of natural or synthetic surfaces and for enhancing the acoustic reflectivity thereof are also disclosed.
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patent: 5616690 (1997-04-01), Axworthy et al.
Urdal et al., "Tumor-associated Ganglio-N-Triosyceramide", Journal of Biological Chemistry, vol. 255, No. 21, pp. 10509-10516, 1980.
Lanza Gregory M.
Wickline Samuel A.
Barnes-Jewish Hospital
Dees Jos,e G.
Hartley Michael G.
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