Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lipoproteins – e.g. – egg yolk proteins – cylomicrons – etc.
Patent
1985-05-21
1986-07-29
Schain, Howard E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lipoproteins, e.g., egg yolk proteins, cylomicrons, etc.
424101, 514 2, 514 8, 530416, C07K 1516
Patent
active
046030107
ABSTRACT:
A process is described for removing low density and very low density lipoproteins from blood plasma or serum and recovering the plasma or serum in a physiologically acceptable form. The method involves in a preferred embodiment passing plasma or serum through a cationic ion exchanger equilibrated with a physiologically acceptable saline solution. The ion exchanger is a water insoluble hydrophilic, water swellable cross-linked regenerated or microgranular cellulose matrix substituted with hydroxy C.sub.2 -C.sub.4 alkyl group. The ion exchanger capacity is provided by sulphate groups substituted with from 2 to 6 meq/g. The take up of low density lipoproteins is enhanced by recycling the plasma through the column.
REFERENCES:
patent: 4096136 (1978-06-01), Ayers et al.
patent: 4178439 (1979-12-01), Ayers et al.
The Lancet (Jun. 12, 1976), 1261-1265, Lupien et al.
Pediat. Res. 14: 113-117 (1980), Lupien et al.
Ayers John S.
Hancock William S.
Harding David R. K.
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