Process for the preparation of 6-hydroxy-2,5,7,8-tetraalkyl-2-(4

Details Process for the preparation of 6-hydroxy-2,5,7,8-tetraalkyl-2-(4 Process for the preparation of 6-hydroxy-2,5,7,8-tetraalkyl-2-(4

1993-02-19

1994-02-08

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D31158

Patent

active

052849619

ABSTRACT:
A novel process for the preparation of aminochromans of the general formula: ##STR1## wherein R is a lower alkyl group having 1 to 4 carbon atoms. In the process, nitrochromanones of the general formula: ##STR2## are reduced using zirconium oxide/isopropanol to give a mixture of a corresponding aminochromene: ##STR3## and a corresponding nitrochromene: ##STR4## The mixture is then hydrogenated with hydrogen in the presence of a hydrogenation catalyst to give the final product. The aminochromans are important intermediates for the preparation of hypolipidaemic pharmaceuticals.

REFERENCES:
patent: 5030601 (1991-07-01), Michel et al.
J. Med. Chem., 32, (1989), pp. 421 to 428.
Shibagaki et al., Bull. Chem., Soc., Japan, 61, (1988), pp. 3283 to 3288.

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