Synthetic tetrapeptides for the prevention of schistosome parasi

Details Synthetic tetrapeptides for the prevention of schistosome parasi Synthetic tetrapeptides for the prevention of schistosome parasi

1991-11-26

1994-02-08

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 514846, 514969, 530323, 530330, 530331, A61K 3710, A61K 3702

Patent

active

052848299

ABSTRACT:
The invention relates to synthetic tetrapeptides that contain a peptide blocking group at the amino terminus and an enzyme inhibitor at the carboxy terminus, and their use in the prevention of schistosome parasite infection.

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Cherfas, J., Science 246, 1242-1232 (1989).
McKerrow, J. H., Pino-Heiss, S., Lindquist, R. and Werb, Z. Journal of Biological Chemistry, 160, 3703-3707 (1985).
Newport, G. R., McKerrow, J. H., Hedstrom, R., Petitt, M. McGarrigle, L. Barr, P. J. and Agabian, N., Journal of Biological Chemistry 263, 13179-13184 (1988).
McKerrow, J. H., Skanari, J., Brown, M., Brindley, P., Railey, J., Weiss, N., and Resnick, S. D., Models in Dermatology, vol. 4, 276-284 (1989).
Amiri, F., Cohen, F. E., Gregoret, L. M., Aldape, K., Railey, J., and McKerrow, J. H., Abstrcts of the 20th Annual Meetings for the Keystone Symposia on Molecular and Cellular Biology (1991).

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