Pyrazolopyridine derivatives and their use in treating inflammat

Details Pyrazolopyridine derivatives and their use in treating inflammat Pyrazolopyridine derivatives and their use in treating inflammat

1985-02-22

1986-11-04

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546119, 546120, A61K 3144, C07D47104

Patent

active

046210890

ABSTRACT:
Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein: X is NR wherein R is hydrogen or C.sub.1-6 alkyl, oxygen, sulphur, SO or SO.sub.2 ;

REFERENCES:
E. Ajello, "New Syntheses of Condensed Heterocycles from Isoxazole Derivatives. II. Pyrazolo [4,3-b] Pyridine," J. Heterocycl. Chem., 1971, 8 (6), 1035-37.
F. M. Dietrich and R. Hess, "Hypersensitivity in Mice," Int. Arch. Allergy, 38: 246-259 (1970).
H. E. Foster and J. Hurst, "Pyrazolopyridines. Part IV. Preparation and Tantomerism of 6-Cyano- and 6-Ethoxycarbonyl-1,4-dihydropyrazolo[4,3-b]pyridin-7-ones", J. Chem. Soc.--Perkin Translation I, 1976 (5), 507.
B. A. Jakschik et al., "Calcium Stimulation of a Novel Lipoxygenase," Biochemical and Biophysical Research Communickations, 95: 103-110 (1980).
R. W. Middleton et al., "N-Methylation of Heterocycles with Dimethylformamide Dimethyl Acetal," Synthesis (1984) 740.
K. F. Swingle et al., "Comparison of Croton Oil and Cantharidin Induced Inflammations of the Mouse Ear and Their Modification by Topically Applied Drugs," Arch. Int. Pharmacodyn. (1981) 254: 168-176.
Chemical Abstracts, 87:168030e, Nov. 21, 1977.

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