Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Enzymatic production of a protein or polypeptide
Patent
1984-06-14
1986-11-04
Marantz, Sidney
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Enzymatic production of a protein or polypeptide
4351722, 435240, 435241, 435284, 435948, 530399, 935106, 935109, C12P 2100, C12N 1500, C12N 500, C12N 502
Patent
active
046210520
ABSTRACT:
The present invention relates to a process for the production of human epidermal growth factor (hEGF). More precisely, the present invention relates to a process for the mass production of hEGF, comprising in vivo or in vitro multiplication of human cells capable of producing hEGF, and in vitro cultivation of the multiplied human cells to produce hEGF. The hEGF production according to the present invention is much higher than that attained by conventional processes; thus, hEGF can be obtained in a sufficient amount for use in the prevention and treatment of human diseases.
REFERENCES:
patent: 3917824 (1975-11-01), Camble et al.
patent: 4135975 (1979-01-01), Lichtman et al.
patent: 4242460 (1980-12-01), Chick et al.
patent: 4276282 (1981-06-01), Sugimoto et al.
patent: 4285929 (1981-08-01), Sugimoto
patent: 4328207 (1982-05-01), Sugimoto
patent: 4377513 (1983-05-01), Sugimoto et al.
patent: 4383034 (1983-05-01), Sugimoto
patent: 4383035 (1983-05-01), Sugimoto
patent: 4383036 (1983-05-01), Sugimoto
Zeleznik et al., Endocrinology, 1979, vol. 105, pp. 156-162.
Lewin, Gene Expression, 2nd ed., John Wiley and Sons, N.Y., 1980, pp. 258-265.
Pattill, Hormone Synthesis and Function in vitro, Growth, Nutrition and Metabolism of Cells in Culture, Academic Press, N.Y., 1972, p. 243.
Bordelon et al, Human Glycoprotein Hormone Production in Human-Human and Human-Mouse Somatic Cell Hybrids, Chem. Abst., vol. 86, 1977, p. 246.
Astaldi et al, J. of Immunology, vol. 125, No. 4, 1411-1414, Oct. 1980.
Peterson, J. A. et al, "Expression of Differentiated Functions in Hepatoma Cell Hybrids: Induction of Mouse Albumin Production in Rat Hepatoma-Mouse Fibroblast Hybrids", Proc. Nat. Acad. Sci., 69:3, 571-75 (1972).
Malawista, S. E. et al, "Expression of Differentiated Functions in Hepatoma Cell Hybrids: High Frequency of Induction of Mouse Albumin Production in Rat Hepatoma-Mouse Lymphoblast Hybrids": Proc. Nat. Acad. Sci., 71:3, 927-31 (1974).
Elder, J. B.: Cellular Localisation of Human Urogastrone/Epidermal Growth Factor: Nature, vol. 271, 466-467 (1978).
Carpenter, Graham, "The Regulation of Cell Proliferation: Advances in the Biology and Mechanism of Action of Epidermal Growth Factor", The Journal of Investigative Dermatology, 71, 283-87 (1978).
Hollenberg, M. D., "Epidermal Growth Factor-Urogastrone, a Polypeptide Acquiring Hormonal Status", Vitamins and Hormones, vol. 37, pp. 69-110 (1979).
Friedman, M. H. F., "Urinary Gastric Secretory Depressants (Urogastrone)", Vitamins and Hormones, vol. 9, 313-353 (1951).
Hirata, Y. et al, "Epidermal Growth Factor (Urogastrone) in Human Tissues", Journal of Clinical Endocrinology and Metabolism, 48:4, pp. 667-672 (1979).
Thompson, J. S. et al, "Heterologous Transplantation of Mouse Tumors into the Newborn Albino Rat", Cancer Research, vol. 20, pp. 1365-1371 (1960).
Bordelon, M. R. et al, "Human Glycoprotein Hormone Production in Human-Human and Human-Mouse Somatic Cell Hybrids", Exp. Cell Research, 103 (1976) 303-310.
DeSantis Patricia L.
Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
Marantz Sidney
LandOfFree
Process for the production of human epidermal growth factor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for the production of human epidermal growth factor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the production of human epidermal growth factor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-697064