Oral osmotic system for slightly soluble active agents

Details Oral osmotic system for slightly soluble active agents Oral osmotic system for slightly soluble active agents

1991-12-16

1994-02-08

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424465, A61K 924

Patent

active

052846628

ABSTRACT:
An oral sustained release composition for slightly soluble pharmaceutically active agents comprising a core, a wall around said core, and a bore through said wall connecting said core and the environment outside of said wall; wherein said core comprises a slightly soluble active agent, optionally a crystal habit modifier, at least two osmotic driving agents, at least two different (or two different grades of) hydroxyalkyl celluloses, and optionally lubricants, wetting agents, and carriers; said wall being substantially impermeable to said core components and permeable to water and gastro-intestinal fluids. The composition is most especially adapted for administering carbamazepine.

REFERENCES:
patent: 4857336 (1989-08-01), Khanna et al.

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