Process for preparing cephalosporines

Details Process for preparing cephalosporines Process for preparing cephalosporines

1977-12-12

1979-02-13

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 28, 544 30, C07D50106

Patent

active

041397029

ABSTRACT:
A process for preparing cephalosporines in which a cephalosporanic derivative is treated with a polar solvent, then with an organic base to give a mixture which is cooled at a temperature lower than -25.degree. C. A cyclic derivative of boron is added to the mixture and the temperature is increased to about 0.degree. C. An intermediate compound is formed which by treatment first with an acylating agent and then with a mixture of water and alcohol provides a solution containing cephalosporines.

REFERENCES:
patent: 3988326 (1976-10-01), Seki et al.
patent: 4029806 (1977-06-01), Krohn et al.
patent: 4051131 (1977-09-01), Robinson

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