Multicellular living organisms and unmodified parts thereof and – Nonhuman animal
Patent
1992-09-10
1998-11-03
Crouch, Deborah
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
800DIG1, 435 691, 435 696, 4351723, 4353207, 536 241, 935 60, C12N 500, C12N 1500, C12P 2106, C12P 2104
Patent
active
058311416
ABSTRACT:
Heterologous polypeptides are produced in the milk of transgenic non-human mammals by the expression of a stably integrated DNA sequence containing the long whey acidic protein promoter operably linked to a DNA sequence encoding a heterologous polypeptide and a signal sequence. The transgenic non-human mammals of the present invention are produced by introducing this DNA sequence such that the DNA sequence is stably integrated into the DNA of germ line cells of the mature mammal and inherited in normal Mendelian fashion. A representative heterologous polypeptide is protein C.
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Drohan William N.
Hennighausen Lother
Lubon Henryk
American Red Cross
Crouch Deborah
United States of America as represented by the Department of Hea
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