Syntheses of optically pure compounds useful as GARFT inhibitors

Details Syntheses of optically pure compounds useful as GARFT inhibitors Syntheses of optically pure compounds useful as GARFT inhibitors

1995-06-07

1998-11-03

Lambkin, Deborah C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 71, 549 72, C07D33322, C07D33338

Patent

active

058311009

ABSTRACT:
The invention relates to methods of making compounds of the formula VII ##STR1## and their enantiomers, where Ar is a substituted or unsubstituted five- or six-membered aromatic group and B is either an amino acid linked through the amino portion to form an amide or a C.sub.1 -C.sub.6 alcohol linked through the alcohol portion to form an ester. These compounds are advantageously employed as intermediates to prepare optically pure compounds that are active GARFT inhibitors. In one method, a compound of the formula ##STR2## is reacted with a compound of the formula ##STR3## where X is a halogen.

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