Process for producing purine derivatives

Details Process for producing purine derivatives Process for producing purine derivatives

1996-02-20

1998-11-03

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544264, 544265, 544267, 544271, 544272, 544273, 544276, 544277, C07D47318, C07D47330, C07D47334, C07D47316

Patent

active

058310924

ABSTRACT:
Purine derivatives in which a desired substituent is introduced into the 9-position only are synthesized by first introducing an easily-removable substituent in the 7-position of a purine base of natural purine nucleosides obtained through fermentation or derivatives thereof, then hydrolyzing the ribose moiety to form purine derivatives having the substituent in the 7-position, subsequently introducing the desired substituent in the 9-position, and then removing the substituent in the 7-position.

REFERENCES:
patent: 5336770 (1994-08-01), Shiragami et al.
Journal of the Chemical Society, pp. 2026-2028, 1968, P. Brookes, et al., "The Preparation and Properties of Some Benzylated Nucleosides".
Tetrahedron Letters, vol. 33, No. 32, pp. 4609-4612, Aug. 4, 1992, G. Green, et al. "Regiospecific Michael Additions with 2-Aminopurines".
Muller, Syn. Comm. 24, 1311 (1994).
Jones et al J. Amer. Chem. Soc 84, 1914.

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