New human translocation associated protein

Details New human translocation associated protein New human translocation associated protein

1997-05-07

1998-11-03

Huff, Sheela

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 435 691, 435 693, 435 711, 4353201, 435273, 4352523, 536 235, 530350, C07H 2102, C07H 2104

Patent

active

058310525

ABSTRACT:
The present invention provides a human translocation associated protein (Gp25L-H) and polynucleotides which identify and encode Gp25L-H. The invention also provides expression vectors, host cells, antibodies and antagonists. The invention also provides methods for the prevention and treatment of diseases associated with expression of Gp25L-H, as well as diagnostic assays.

REFERENCES:
Palade, G. "Intracellular aspects of the process of protein synthesis." Science (1975) 189(4200):347-358.
Parlati, F. et al., "Saccharomyces cerevisiae CNE1 encodes an endoplasmic reticulum (ER) membrane protein with sequence similarity to calnexin and calreticulin and functions as a constituent of the ER quality control apparatus." J. Biol. Chem. (1995) 270(1): 244-253.
Wada, I. et al., "SSR.alpha. and Associated Calnexin Are Major Calcium Binding Proteins of the Endoplasmic Reticulum Membrane." J. Biol. Chem. (1991) 266(29) 19599-19610 (GI 848).
Holthuis J. C. M. et al., "Translocon-associated protein TRAP.delta. and a novel TRAP-like protein are coordinately expressed with pro-opiomelanocortin in Xenopus intermediate pituitary." Biochem. J. (1995) 312: 205-213 (GI 1063411).
Dominguez, M. (Direct Submission), GenBank Sequence Database (Accession X90872), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894. (GI 996057) (1995).
Domingues, M. (Direct Submission), GenBank Sequence Database (Accession X90872), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894. (GI 996056) (1995).
Walter, P. et al., "Preparation of microsomal membranes for cotranslational protein translocation." Methods Enzymol. (1983) 96:84-93.
Bergeron, J. J. et al., "Calnexin: a membrane-bound chaperone of the endoplasmic reticulum." Trends Biochem. Sci. (1994) 19(3) :124-128.

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