Human thioredoxin

Details Human thioredoxin Human thioredoxin

1997-01-03

1998-11-03

Huff, Sheela

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 235, 530350, 4353201, 435 691, 435 693, 435 6, 435273, 4352523, C07H 2102, C07H 2104

Patent

active

058310495

ABSTRACT:
The present invention provides a human thioredoxin (TRDX) and polynucleotides which identify and encode TRDX. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding TRDX and a method for producing TRDX. The invention also provides for agonists, antibodies, or antagonists specifically binding TRDX, and their use, in the prevention and treatment of diseases associated with expression of TRDX. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding TRDX for the treatment of diseases associated with the expression of TRDX. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding TRDX in the production of recombinant proteins. The invention also provides for the use of purified TRDX in the production of recombinant proteins. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding TRDX.

REFERENCES:
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Tagaya, Y., et al., "ATL-derived factor (ADF), an IL-2 receptor/Tac inducer homologous to thioredoxin; possible involvement of dithiol-reduction in the IL-2 receptor induction," The EMBO Journal, 8(3)757-764 (1989).
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Rosen, A., et al., "A CD4+ T cell line-secreted factor, growth promoting for normal and leukemic B cells, identified as thioredoxin," International Immunology, 7(4) 625-633 (1994).
Miranda-Vizuete, A., et al., "The Levels of Ribonucleotide Reductase, Thioredoxin, Glutaredoxin 1, and GSH are Balanced in Escherichia coli K12*," The Journal of Biological Chemistry, 271(32) 19099-19103 (1996).
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Watabe, S. (GI 1545817) GenBank Sequence Database (Accession N30487) National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 2084.
Luthman, M., et al., "Rat Liver Thioredoxin and Thioredoxin Reductase: Purification and Characterization," Biochemistry, 21:6628-6633.

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