Capsid polypeptides and use to inhibit viral packaging

Details Capsid polypeptides and use to inhibit viral packaging Capsid polypeptides and use to inhibit viral packaging

1996-07-02

1998-11-03

Scheiner, Laurie

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

424 932, 435 691, 4351723, 4352523, 530826, A01N 6300

Patent

active

058310134

ABSTRACT:
The present invention is directed to a viral capsid polypeptide capable of inhibiting viral packaging, the viral capsid polypeptide consisting of a portion of a viral capsid protein of an RNA virus and including a multimerization domain of the viral capsid protein. The invention further provides an isolated nucleic acid molecule encoding such a viral capsid polypeptide. Expression vectors and host cells comprising the nucleic acid molecules are also provided, as well as a method for inhibiting viral packaging in a host cell by expressing the viral capsid polypeptide. In two preferred embodiments, the RNA virus is the ScVL1 virus or the ScVLa virus of Saccharomyces cerevisiae.

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