Compounds, compositions and methods for treatment of hepatitis C

Details Compounds, compositions and methods for treatment of hepatitis C Compounds, compositions and methods for treatment of hepatitis C

1996-03-29

1998-11-03

Woodward, Michael P.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546184, 546186, 546187, A61K 31445, C07D40106

Patent

active

058309055

ABSTRACT:
Derivatives of piperidine are useful in prophylaxis and treatment of hepatitis C virus infections.

REFERENCES:
patent: 5633388 (1997-05-01), Diana et al.
Choo et al., "Isolation of a cDNA Clone Derived from a Blood-Borne Non-A, Non-B Viral Hepatitis Genome," Science, 244:359-362 (1989).
Lain et al., "RNA Helicase: a Novel Activity Associated with a Protein Encoded by a Positive Strand RNA Virus," Nucleic Acids Res. 18:7003-7006 (1991).
Warrener et al., "Pestivirus NS3 (p80) Protein Possesses RNA Helicase Activity," J. Virol. 69:1720-1726 (1995).
Kim et al., "Rapid Isolation of Cell-Type Specific Protein Tyrosine Kinases by Degenerate Polymerase Chain Reaction Combined with Differential Hybridization Technique," Biochem. Biophys. Res. Comm. 214:60-68 (1995).
McConnaughie et al., "Design and Synthesis of RNA-Specific Groove-Binding Cations: Implications for Antiviral Drug Design," J. Med. Chem. 37:1063-1069 (1994).

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