Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-09-08
1998-11-03
Kemmerer, Elizabeth C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 12, 514 13, 514 14, 514 15, 514 16, 514 17, 530326, 530327, 530328, 530329, 530331, 530306, 530 70, 4251851, 4251981, A61K 3804, A61K 3806, A61K 3822
Patent
active
058308660
ABSTRACT:
The invention features a substantially pure preparation of a peptide having corticotropin release inhibiting factor (CRIF) activity comprising at least three contiguous amino acids contained within the amino acid sequence positioned between the fourth and fifth thyrotropin releasing hormone (TRH) sequence on a prepro-TRH protein. The CRIF peptide further comprises the fourth uncleaved TRH portion of prepro-TRH positioned at the amino terminus of CRIF. Compositions, methods of diagnosis and methods of treating CRIF related diseases are also included in the invention.
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Aird Fraser
Redei Eva
Kemmerer Elizabeth C.
Romeo David S.
The Trustees of the University of Pennsylvania
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