Substituted glucose compounds for toxic metal ion removal from t

Details Substituted glucose compounds for toxic metal ion removal from t Substituted glucose compounds for toxic metal ion removal from t

1997-08-19

1998-09-29

Reamer, James H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 173, A61K 3170

Patent

active

058146148

ABSTRACT:
According to the present invention, a pharmaceutical composition that comprises a compound which is a 2-deoxy-D-glucopyranose substituted in the 2 position and is of the general formula (I): ##STR1## where x.sub.n is --NHCO(CH.sub.2).sub.m CHR.sup.2 -- and m and n are 0 or 1; and R.sup.1 is selected from methyl or ethyl, and R.sup.2 is hydrogen or a substituent group selected from CH.sub.3 --, (CH.sub.3).sub.2 CH--, (CH.sub.3).sub.2 CHCH.sub.2 --, CH.sub.3 CH.sub.2 CH(CH.sub.3)--, CH.sub.3 SCH.sub.2 CH.sub.2 --, C.sub.6 H.sub.5 --CH.sub.2 --, HOCH.sub.2 --, CH.sub.3 CH(OH)--, HSCH.sub.2 --, HO--C.sub.6 H.sub.4 --CH.sub.2 --, H.sub.2 NCOCH.sub.2 --, H.sub.2 NCOCH.sub.2 CH.sub.2 --, HOCOCH.sub.2 --, HOCOCH.sub.2 CH.sub.2 --, H.sub.2 NCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 --, H.sub.2 NC(NH)NHCH.sub.2 CH.sub.2 CH.sub.2 --, ##STR2## or a physiologically acceptable salt thereof. The pharmaceutical compositions are useful in the treatment of metal intoxication where the metal is selected from ionized iron or aluminum.

REFERENCES:
Mao et al, Chemical Abstracts, vol. 100, #51933x, 1984.
Liu et al, Nucleosides & Nucleotides, vol. 14, pp. 1901-1904, 1995.

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