Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-01-17
1998-09-29
Patterson, Jr., Charles L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
475191, 4753201, 4752523, 536 232, C12Q 168, C12N 906
Patent
active
058144510
ABSTRACT:
The present invention provides four NADH dehydrogenase subunits (designated individually as NDS-1, NDS-2, NDS-3, and NDS-4 and collectively as NDS) and polynucleotides which identify and encode NDS. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NDS and a method for producing NDS. The invention also provides for use of NDS and agonists, antibodies, or antagonists specifically binding NDS, in the prevention and treatment of diseases associated with expression of NDS. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NDS for the treatment of diseases associated with the expression of NDS. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NDS.
REFERENCES:
Cleeter, M., et al., "The polypeptide composition of the mitochondrial NADH: ubiquinone reductase complex from several mammalian species," Biochem. J., 230:739-746 (1985).
Walker, J., et al., "Sequences of 20 Subunits of NADH: Ubiquinone Oxidoreductase from Bovine Heart Mitochondria," J. Mol. Biol., 226:1051-1072 (1992).
Pilkington, S., et al., "The 30-Kilodalton Subunit of Bovine Mitochondrial Complex I Is Homologous to a Protein Coded In Chloroplast DNA," Biochem.,30:1901-1908 (1991).
Arizmendi, J., et al., "Complementary DNA sequences of two 14.5 kDa subunits of NADH:ubiquionone oxidoreductase from bovine heart mitochondria," FEBS lett 313(1):80-84 (1992).
Bandman Olga
Goli Surya K.
Hillman Jennifer L.
Billings Lucy J.
Incyte Pharmaceuticals Inc.
Patterson Jr. Charles L.
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