Process for preparing 3-hydroxy-5-methylisoxazole

Details Process for preparing 3-hydroxy-5-methylisoxazole Process for preparing 3-hydroxy-5-methylisoxazole

1984-04-05

1987-01-06

Hendricks, Glenna M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D26112

Patent

active

046347747

ABSTRACT:
3-hydroxy-5-methylisoxazole is prepared by reacting diketene in a continuous process with hydroxylamine to give a reaction mixture containing acetoacetohydroxamic acid and then acidifying this reaction mixture as quickly as possible to produce the 3-hydroxy-5-methylisoxazole.

REFERENCES:
patent: 3687968 (1972-08-01), Iwai et al.
Kato, et al., "Ketene and Its Derivatives", Chem. Abst. 77:126375j.
Rahman, et al., "Reaction of .alpha.-Keto Ketene . . . ," Chem Abst. 101: 54964q.
Jacobsen, et al., "3-Hydroxyisoxazoles", Chem Abst. 101: 191881z (1984).
Kato et al, "Studies on Ketene and Its Derivatives XLVIII Reaction of Diketene with Hydroxylamine", Chem. Pharm Bul., vol. 20 (1972) pp. 1368-1373.
Khromov, "The Oxime of Acetoacetic Acid" (.beta.-Oximinobutyric Acid) Chem. Abstracts, 45: 2868i (1950).
Fujimoto et al, Derive d'Isoxazol. I. Sur les Reactions Entre du Dicetene et de l'Hydroxylamine ou de Quelques Acides Hydroxamiques, Chem. Pharm. Bul., vol. 13 (1965) pp. 248-252.

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