Antihypertensive 3-(ureidocyclohexyleneamino)propane-1,2-diol de

Details Antihypertensive 3-(ureidocyclohexyleneamino)propane-1,2-diol de Antihypertensive 3-(ureidocyclohexyleneamino)propane-1,2-diol de

1985-08-19

1987-01-06

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546210, 546234, 260239BC, 546278, 546288, 2602433, 546300, 548135, 2602444, 548146, 548215, 2602455, 548318, 548320, 2602457, 548503, 548560, 514218, 564 27, 564 47, 514222, 514228, 514235, 514274, 514312, 514326, 514331, 514340, 514341, 514365, 514374, 514415, 514429, 514586, 514597, 544 581, 544 585, 544 586, 544123, 544134, 544160, 544165, 544316, 546141, 546142, 546165, A61K 31415, C07D23334

Patent

active

046347135

ABSTRACT:
Certain 3-(ureidocyclohexyleneamino)propane-1,2-diol derivatives, such as the compounds of formula III below, represent novel and useful pharmaceutical agents, e.g. potent antihypertensive and cardioactive agents demonstrating both .alpha.- and .beta.-adrenergic blocking activity. ##STR1## R.sub.3 is hydrogen or lower alkyl; R.sub.7 is cyano, lower alkoxycarbonyl, pyrrolyl, morpholino, alkenyloxy of 3 to 6 carbon atoms, alkynyloxy of 3 to 6 carbon atoms, alkoxy of 1 to 3 carbon atoms substituted by cyclopropyl.

REFERENCES:
patent: 3852291 (1974-12-01), Augstein et al.
patent: 4041075 (1977-08-01), Smith
patent: 4131685 (1978-12-01), Smith
patent: 4171374 (1979-10-01), Smith
patent: 4260632 (1981-04-01), Smith
patent: 4387099 (1983-06-01), Smith
patent: 4515814 (1985-05-01), Wick et al.
patent: 4521414 (1985-06-01), Chiou et al.
Chiou, G., Biochemical Pharmacology, vol. 30, pp. 103-106 (1981).

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