Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation
Patent
1996-03-18
1998-09-29
Lateef, Marvin M.
Surgery
Diagnostic testing
Detecting nuclear, electromagnetic, or ultrasonic radiation
600473, 356432, 356446, A61B 500
Patent
active
058139885
ABSTRACT:
A method for imaging objects in highly scattering turbid media. According to one embodiment of the invention, the method involves using a plurality of intersecting source/detectors sets and time-resolving equipment to generate a plurality of time-resolved intensity curves for the diffusive component of light emergent from the medium. For each of the curves, the intensities at a plurality of times are then inputted into the following inverse reconstruction algorithm to form an image of the medium: W+.LAMBDA.!.sup.-1
wherein W is a matrix relating output at detector position r.sub.d, at time t, to source at position r.sub.s, .LAMBDA. is a regularization matrix, chosen for convenience to be diagonal, but selected in a way related to the ratio of the noise, <nn> to fluctuations in the absorption (or diffusion) X.sub.j that we are trying to determine:
REFERENCES:
patent: 5213105 (1993-05-01), Gratton et al.
patent: 5353799 (1994-10-01), Chance
patent: 5371368 (1994-12-01), Alfano et al.
patent: 5416582 (1995-05-01), Knutson et al.
patent: 5441054 (1995-08-01), Tsuchiya
patent: 5555885 (1996-09-01), Chance
patent: 5596987 (1997-01-01), Chance
patent: 5644429 (1997-07-01), Alfano et al.
Alfano et al. "Photons for Prompt Tumour Detection", Physics World, pp. 37-40, Jan. 1992.
Wang et al., "Ballistic 2-D Imaging Through Scattering Walls Using an Ultrafast Optical Kerr Gate," Science, 253:769-71 (1991).
Das et al., "Ultrafast time-gated imaging in thick tissues: a step toward optical mammography," Opt. Lett., 18:1092-4 (1993).
Alfano et al., "Time-Resolved Imaging of Translucent Droplets in Highly Scattering Turbid Media," Science, 264:1913-5 (1994).
Huang et al., "Optical Coherence Tomography," Science, 254:1178-81 (1991).
Chance et al., "Highly sensitive object location in tissue models with linear in-phase and anti-phase multi-element optical arrays in one and two dimensions," Proc. Natl. Acad. Sci. USA, 90:3423-7 (1993).
Fishkin et al., "Propagation of photon-density waves in strongly scattering media containing an absorbing semi-infinite plane bounded by a straight edge," J. Opt. Soc. Am. A, 10(1):127-40 (1993).
Singer et al., "Image Reconstruction of the Interior of Bodies That Diffuse Radiation," Science, 248:990-3 (1990).
Arridge, "The Forward and Inverse Problems in Time Resolved Infra-red Imaging," Medical optical tomography: functional imaging and monitoring, SPIE Institutes, vol. IS11, G. Muller ed., pp. 31-64 (1993).
Barbour et al., "A Perturbation Approach for Optical Diffusion Tomography Using Continuous-Wave and Time-Resolved Data," Medical optical tomography: functional imaging and monitoring, SPIE Institutes, vol. IS11, G. Muller ed., pp. 87-120 (1993).
Shaw, Jr., "Improvement of the Resolution of an Instrument by Numerical Solution of an Integral Equation," J. Math. Analys. and Applic., 37:83-112 (1972).
Alfano Robert R.
Cai Wei
Das Bidyut B.
Lax Melvin
Liu Feng
Lateef Marvin M.
Research Foundation
Shaw Shawna J.
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