Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-11-07
2000-02-29
Ulm, John
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 701, 435325, 4353201, 435243, 436 2351, 530399, C12N 1512, C12N 1563, C12N 121, C12N 500
Patent
active
060308117
ABSTRACT:
A human cDNA encoding human myotrophin and the polypeptide encoded thereby and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing the human myotrophin polynucleotides and polypeptides encoded thereby for the treatment of diseases relating to cellular hypertrophy, among others. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides.
REFERENCES:
George et al. Macromolecular Sequencing & Synthesis. pp. 127-149, 1988.
Sivasubramanian et al., "Cardiac Myotrophin Exhibits rel/NF-kB Interacting Activity in Vitro", Journal of Biological Chemistry, 271(5), pp. 2812-2816 (1996).
Sen et al., "Myotrophin:Purification of a Novel Peptide from Spontaneously Hypertensive Rat Heat That Influences Myocardial Growth", Journal of Biological Chemistry, 265(27), pp. 16635-16643 (1990).
Sil et al., "Myotrophin in Human Cardiomyopathic Heart", Circulation Research, 73, pp. 98-108 (1993).
Pennica et al., "Isolation of cDNA clones encoding the mouse protein V-1*", Gene, 158, pp. 305-306 (1995).
Sawada, K., "Characterization of terminally differentiated cell state by etc.", Accession No. D26326 (1996).
Anderson Karen M
Chabot-Fletcher Marie
Han William T.
King William T.
Saoud Christine
SmithKline Beecham Corporation
Ulm John
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