Antisense modulation of RhoC expression

Details Antisense modulation of RhoC expression Antisense modulation of RhoC expression

1998-09-18

2000-02-29

Elliott, George C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 911, 435325, 435366, 536 231, 536 2431, 536 245, C12Q 168, C12P 1934, C07H 2104, C12N 1585

Patent

active

060307862

ABSTRACT:
Antisense compounds, compositions and methods are provided for modulating the expression of RhoC. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding RhoC. Methods of using these compounds for modulation of RhoC expression and for treatment of diseases associated with expression of RhoC are provided.

REFERENCES:
Hall, Rho GTPases and the actin cytoskeleton, Science, 1998, 279:509-514.
Khosravi-Far et al., Increasing complexity of Ras signal transduction: involvement of Rho family proteins, Adv. Cancer Res., 1998, 72:57-107.
Narumiya et al., rho gene products, botulinum C3 exoenzyme and cell adhesion, Cell Signal, 1993, 5:9-19.
Ridley et al., The samll GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors, Cell, 1992, 70:389-399.
Suwa et al., Overexpression of rhoC gene correlates with progression of ductal adencarcinoma of the pancreas, Br. J. Cancer, 1998, 77:147-152.
Takada et al., The involvement of rho gene product, a small molecular Iight GTP-binding protein, in polyploidization of a human megakaryocytic cell line, CMK, Exp. Hematol., 1996, 24:524-530.

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