Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1975-04-10
1976-05-04
Turner, V. D.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
424267, 424272, A01N 922
Patent
active
039549852
ABSTRACT:
There is provided, novel 3-chloro-tetrahydro-1,3-oxazine or oxazolidine compounds, exhibiting antibacterial activity and being of low chlorine potential of the formula: ##SPC1##
Wherein each of R.sub.1 and R.sub.2, which may be the same or different, represent an alkyl group of from 1 to 20 carbon atoms (C.sub.1 -C.sub.5 being preferred); wherein each of R.sub.5 and R.sub.6, which may be the same or different, represent a hydrogen atom or an alkyl group of from 1 to 20 carbon atoms (C.sub.1 -C.sub.5 being preferred); wherein l represents an integer of 1 or 2 and wherein each of R.sub.3 and R.sub.4, which may be the same or different, represent an alkyl group of from 1 to 20 carbon atoms (C.sub.1 -C.sub.5 being preferred), a --(CH.sub.2).sub.n X group, wherein n represents an integer of from 1 to 20 and wherein X represents a dimethylamino group, a diethylamino group, a trimethylammonium group, a triethylammonium group, a dimethylammonium group, a diethylammonium group, a --COOR.sub.7 group, a --OOCR.sub.8 group and, a --OR.sub.9 group, wherein each of R.sub.7 through R.sub.9, respectively, represent an alkyl group of from 1 to 5 carbon atoms or a benzyl group. In addition, R.sub.3 and R.sub.4 can also represent a ##EQU1## group, wherein Y represents a --(CH.sub.2).sub.n --W--(CH.sub.2).sub.m -- group or a >CH--Z group, wherein W represents a --O-- atom, a --CH.sub.2 -- group, a >NCH.sub.3 -- group, a >NHCH.sub.3 .sup.+ group, a >NC.sub.2 H.sub.5 group, a >NHC.sub.2 H.sub.5 .sup.+ group, a >N(CH.sub.3).sub.2 .sup.+ group, or a >N(C.sub.2 H.sub.5).sub.2 .sup.+ group, wherein n is the same or different from m and wherein each of n and m represent an integer of from 0 to 2; and wherein Z is defined in accordance with X above.
REFERENCES:
patent: 2843586 (1958-07-01), Melamed
patent: 3281310 (1966-10-01), Danielson
patent: 3591601 (1971-07-01), Walles
patent: 3707541 (1972-12-01), Lajiness
patent: 3798218 (1974-03-01), Fauran et al.
patent: 3817994 (1974-06-01), Teller et al.
Bodor Nicolae S.
Kaminski James J.
Blitzer Charles N.
Interx Research Corporation
Turner V. D.
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