Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Extracorporeal or ex vivo removal of antibodies or immune...
Patent
1996-04-16
2000-02-29
Burke, Julie
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Extracorporeal or ex vivo removal of antibodies or immune...
4241531, 4241561, 4241731, 4241451, 4241581, 424 9371, 435 7021, 435 696, 5303871, 5303882, 53038825, A61K 39395, C07K 1628
Patent
active
060306149
ABSTRACT:
The invention provides a method to prevent or ameliorate hyperacute or acute rejection of a human donor organ transplanted to a human recipient. Hyperacute rejection would normally occur after a human subject receives a transplanted human organ against which the subject has preformed anti-HLA antibodies. Acute rejection occurs when the recipient of a human organ forms antibodies against that organ after transplant. The invention method comprises passing the plasma of the recipient over a sterile and pyrogen-free column coupled to anti-human immunoglobulin antibodies which bind to and remove a significant portion of the immunoglobulin from the subject's plasma.
REFERENCES:
patent: 5560911 (1996-10-01), Koren et al.
Bannett et al. (1987) Transplantation Procedings. vol. 19 No. 6: 4543-4546.
du Moulin et al. (1993) Blood Purif. vol. 11: 145-149.
Palmer et al. (1989). The Lancet Jan. 7, 1989 p. 10-12.
Euler et al. (1992) Transfus. Sci. vol. 13: 167-184.
Morrison (1992) Ann. Revs. Imunvol. vol. 10 239-265.
The Lancet Aug. 25 1990 Editonal: Consensus on Ivig. p. 470-471.
Bieber Franz A.
Bohm Wolfgang
Koll Robert
Muller-Derlich Jutta
Spaethe Reiner
Burke Julie
Plasmaselect GmbH Teterow
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