PGB.sub.3 analogs

Details PGB.sub.3 analogs PGB.sub.3 analogs

1974-10-30

1976-05-04

Gerstl, Robert

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260211R, 2602472R, 260268R, 26024305, 2603262, 260408, 260410, 2604105, 2604109R, 260413, 2604249, 260439R, 260448R, 260468D, 2605011, 26050115, 26050117, 2605012, C07C 6138, C07C 6971

Patent

active

039548511

ABSTRACT:
This disclosure relates to prostaglandins of the PG.sub.3 series including PGE.sub.3, PGF.sub.3.sub..alpha., PGF.sub.3.sub..beta., PGA.sub.3, and PGB.sub.3, to various analogs of those in racemic form, and to novel processes for making those. This disclosure also relates to certain fluorine and alkyl substituted analogs and certain acetylenic analogs of PGE.sub.3, PGF.sub.3.sub..alpha., PGF.sub.3.sub..beta., PGA.sub.3, and PGB.sub.3 in both racemic and optically active form, and to processes for making those. These various analogs are useful for the same pharmacological purposes as the known optically active forms of PGE.sub.3, PGF.sub.3.sub..alpha., PGF.sub.3.sub..beta., PGA.sub.3, and PGB.sub.3, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement, fertility control, and wound healing.

REFERENCES:
Green et al., J. Lipid Research, 5, 117, (1964).

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