Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-05-27
1997-02-04
Kight, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514185, 424450, 530359, 540145, A01N 4338, A01N 5502, C07K 100, C07B 4700
Patent
active
055998313
ABSTRACT:
A method of preparing a pharmaceutically beneficial, pH-sensitive amphipathic drug compound is disclosed. The pH-sensitive amphipathic parent drug compound is converted to a lipophilic derivative which is then combined with a lipophilic carrier for delivery to the lysosomes of target cells. The lipophilic derivative of the parent compound is acted upon by lysosomal enzymes to yield the parent compound. The method is demonstrated for pharmaceutically beneficial porphyrins that may be used as photosensitizers in photodynamic therapy (PDT). In particular, the method is demonstrated for the esterification of chlorin e.sub.6 and pheophorbide a for the photocytotoxic treatment of human bladder tumor cells.
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Chernomorsky Simon A.
Poretz Ronald D.
Kight John
Leary Louise
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