Process for preparing cefazolin

Details Process for preparing cefazolin Process for preparing cefazolin

1974-09-12

1976-05-04

Coughlan, Jr., Paul M.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D50106

Patent

active

039547450

ABSTRACT:
Cefazolin is prepared by treating a solvate of N,N-dimethylformamide and the hydrochloride salt of 7-amino-3-(2-methyl-1,3,4-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid with 1H-tetrazole-1-acetyl chloride in the presence of N,N-dimethylacetamide as solvent.

REFERENCES:
patent: 3502665 (1970-03-01), Wetherill et al.
patent: 3516997 (1970-06-01), Takano et al.

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