Pharmaceutical compositions

Details Pharmaceutical compositions Pharmaceutical compositions

1995-02-17

1998-11-03

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546296, A61K 3144, C07D21369

Patent

active

RE0359483

ABSTRACT:
Pharmaceutical compositions containing a 3-hydroxypyrid-2-one or 3-hydroxypyrid one in which the hydrogen atom attached to the nitrogen atom is replaced by an aliphatic acyl group, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by one or, except in the case of ionizable groups, more than one substituent selected from aliphatic acyl, alkoxy, aliphatic amine, aliphatic amide, carboxy, aliphatic ester, halogen, hydroxy and sulpho groups and, optionally, in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by one of said substituents, by an aliphatic hydrocarbon group, or by an aliphatic hydrocarbon group substituted by an alkoxy, aliphatic ester, halogen or hydroxy group, but excluding compounds in which said replacement of hydrogen atoms in the compound is effected only by aliphatic hydrocarbon groups, or a salt thereof containing a physiologically acceptable ion or ions, are of value for removing toxic amounts of metals, particularly iron, from the body.

REFERENCES:
patent: Re34313 (1993-07-01), Hider et al.
patent: 3016372 (1962-01-01), Krimmel
patent: 3419570 (1968-12-01), Brammer et al.
patent: 3847927 (1974-11-01), Dunbar et al.
patent: 3963729 (1976-06-01), Gittos et al.
patent: 4131131 (1978-12-01), Lindenbaum et al.
patent: 4550101 (1985-10-01), Hider et al.
patent: 4587240 (1986-05-01), Hider et al.
patent: 4666927 (1987-05-01), Hider et al.
patent: 4840958 (1989-06-01), Hider et al.
patent: 4912118 (1990-03-01), Hider et al.
patent: 5104865 (1992-04-01), Hider et al.
patent: 5177068 (1993-01-01), Callingham et al.
H. Hashiguchi et al. "Inhibition of two copper-containing enzymes, . . . " Molecular Pharmacology, 13, pp. 362-367.
J. Brammer Petersen, et al. The Chemistry of Endialone, printed in Denmark 1967, pp. 1-23.
C. G. Pitt et al., The Design and Synthesis of Chelating Agents for the Treatment of Iron Overload in Colley's Anemia, Research Triangle Institute, DHEW Publication No. 77-994, 1975.
B. Tamhina et al., Extraction and Spectrophotometric Determination of Iron (III) by 1-Phenyl-2-Methyl-3-Hydroxy-4-Pyridone Croatica Chemica Acta CCACAA 45 (4), 603-610 (1973).
J. A. Berson et al., Spectra as a Guide to Structure in the Hydroxypyrone and Hydroxypyridone Series, Dept. of Chemistry, University of Southern California, 1955.
Jacobs, Screening for Iron Chelating Drugs, Elsevier North Holland, Inc., 1981, pp. 39-46.
Wilson et al., Chelation and Biologic Action, Textbook of Organic Medicinal and Pharmaceutical Chemistry, Third Edition, J. B. Lippincott Company, Philadelphia, Pa., 1956, pp. 25-27.
Chemical Abstracts, vol. 90, #186151m, Jun. 4, 1979.
Chemical Abstracts, vol. 90, #167745s, May 21, 1979.
Chemical Abstracts, vol. 89, #37739m, Jul. 31, 1978.
Chemical Abstracts, vol. 86, #167059p, Jun. 6, 1977.
Chemical Abstracts, vol. 85, #104644j, Oct. 11, 1976.
Chemical Abstracts, vol. 80, #103826e, May 13, 1974.
Chemical Abstracts, vol. 77, #122732a, Nov. 6, 1972.
Journal of Medicinal Chemistry, 17, No. 1, 1974, The American Chemical Society, L. E. Hare et al.: "Aromatic Acid Hydroxylase Inhibitors . . . ".
Chemical Abstracts, vol. 86, #12119e, Jan. 17, 1977.
Bulletin of the Chemical Society of Japan, 52, No. 1, Jan. 1979, K. Imafuku et al.: Substituent Effects on 6-Substituted 3-Hydroxy . . . .
Chemical Abstracts, vol. 85, #143377u, Nov. 8, 1976.
Chemical Abstracts, vol. 76, #71652u, Mar. 27, 1972.
Z. Lebensm. Unters. Forsch., T. Severin et al., 1976, Formation of Pyridone Derivatives from Maltose and Lactose, XII, Investigations on the Maillard . . . .
Bulletin of the Chemical Society of Japan, 52(1), 107-110 (1979) Jan., K. Imafuku et al.: Structure of 5-Hydroxy-2-. . . .
Journal of Medicinal Chemistry, 22, No. 1, Jan. 1979, p. 99, J. G. Atkinson et al., Kojic Amine-a Novel . . .
Chemical Abstracts, vol. 74, #23102b, Feb. 1, 1971.
Chemial Abstracts, vol. 97, #92049a, Sep. 13, 1982.

Affiliated with

Also associated with

Rating

Pharmaceutical compositions does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pharmaceutical compositions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmaceutical compositions will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-677768