ErbB2/neu targeted ribozymes

Details ErbB2/neu targeted ribozymes ErbB2/neu targeted ribozymes

1995-05-05

1997-02-04

LeGuyader, John L.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435 6, 435 9131, 4351723, 4353201, 435366, 536 231, 536 232, 536 245, 514 44, C07H 2104, C12N 1585, C12Q 168

Patent

active

055997040

ABSTRACT:
An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of breast cancer.

REFERENCES:
patent: 5168053 (1992-12-01), Altman et al.
patent: 5225337 (1993-07-01), Robertson et al.
patent: 5298612 (1994-03-01), Jennings et al.
Guerrier-Takada et al., "The RNA Moiety of Ribonuclease P Is the Catalytic Subunit of the Enzyme," Cell 35: 849-857 (1983).
Hampel and Tritz, "RNA Catalytic Properties of the Minimum (-)sTRSV Sequence," Biochemistry 28: 4929-4933 (1989).
Hampel et al., "`Hairpin` Catalytic RNA Model: Evidence for Helices and Sequence Requirement for Substrate RNA", Nucleic Acids Research 18: 299-304 (1990).
Haseloff and Gerlach, "Simple RNA Enzymes with New and Highly Specific Endoribonuclease Activities," Nature 334: 585-591 (1988).
Hua et al., "Mechanism of bcl-2 activation in human follicular lymphoma," Oncogene 5: 233-235 (1990).
Mamone et al., "Design of Hammerhead Ribozymes Targeted to Sequences in HIV, HSV and the RAT ANF Gene," Abstract of Keystone, CO (May 27, 1992).
Pavco et al., "Regulation of Self-Splicing Reactions by Antisense RNA," Abstract of Keystone, CO (May 27, 1992).
Perrotta and Been, "Cleavage of Oligoribonucleotides by a Ribozyme Derived from the Hepatitis .delta. Virus RNA Sequence," Biochemisstry 31: 16-21 (1992).
Sarver et al., "Ribozymes as Potential Anti-HIV-1 Therapeutic Agents" Science 247: 1222-1225 (1990).
Semba, "A v-erbB-Related Protooncogene, C-erB-2, Is Distinct From the c-erbB-1/Epidermal Growth Factor-Receptor Gene and Is Amplified in A Human Salivary Gland Adenocarcinoma," Proc. Natl. Acad. Sci. USA 82: 6497-6501 (1985).
Seto et al., "Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2II-Ig fusion gene in lymphoma," EMBO Journal 7: 123-131 (1988).
Weerasinghe et al., "Resistance to Human Immunodeficiency Virus Type 1 (HIV-1) Infection in Human CD4.sup.+ Lymphocyte-Derived Cell Lines Conferred by Using Retroviral Vectors Expressing an HIV-1 RNA-Specific Ribozyme," Journal of Virology 65: 5531-4 (1994).
Zabrecky et al., "The Extracellular Domain of p185
eu is Released from the Surface of Human Breast Carcinoma Cells, SK-BR-3," J. Biol. Chem. 266: 1716 (1991).
Johnston et al. Science 260: 1286 (1993) cited and provided in related Ser. No. 08/435541.
Barinaga Science 262: 1512 (1993) cited and provided in related Ser. No. 08/435541.
Stull et al. Pharm. Reg. 12: 465 (1995) cited and provided in related Ser. No. 08/435541.
Semba et al. PNAS 82:6497 (1985) cited and provided in parent Ser. No. 07/936531.
Sarvec et al. Science 247: 1222 (1990) cited and provided in parent Ser. No. 07/936531.
Hampel et al. NAR 18: 299 (1990).
Perrotta et al. Biochemistry 31: 16 (1992).
Kim et al. 117: 179 (1992). Gene.
Cech et al. 260: 3030 (1988) JAMA.

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